The Function of Telomerase

When the cell replicates and divides, the sequence of nucleotides slowly gets shorter, and the telomere length declines as well. The shortening of the telomeres is believed to be the source of cellular damage, causing the cell division process to slow down as well. Slow, cellular decline leads to dysfunction which causes death. The telomerase enzyme helps to stop the loss of gene information during DNA replication.  The telomerase enzyme is at the helm for maintaining cell division behaviors.

Many different proteins and a string of RNA make up telomerase. Telomerase enzymes seem to halt the cellular cycle of aging by giving extra DNA data to the chromosomes. Telomerase enzymes allow the cells to divide, and allow for cell regeneration.   Many scientists are coming to the conclusion that it is possible to reverse aging with the telomerase enzyme in this lifetime!

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Short Telomeres Contribute to Emphysema in Smokers

New research shows the role of short Telomeres in emphysema, a lung disease mostly developed in people who smoke cigarettes. This is a deadly disease for which no treatment has been found yet.

In emphysema, the alveoli, which are the small air sacs that exchange oxygen in the lungs, are lost. This means less oxygen can be inhaled and therefore less oxygen is available in the body. This is most commonly found in older people who smoke and sometimes, yet very rarely, in non-smokers.

This disease is one of the top 10 causes of death in the United States with growing numbers. Mary Armanios, MD, assistant professor of oncology at the Johns Hopkins School of Medicine said: “We found that in mice that have short telomeres, there was a significant increased risk of developing emphysema after exposure to cigarette smoke.” The study was lead by Dr Armanios and her colleagues. The mice were exposed to cigarette smoke for 6 hours a day, 5 days a week for six months.

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Telomere Studies May Explain Rare Aging Disease in Children

Study of children with rare case of genetic mutation that causes drastic early aging and death is now being linked to short or missing Telomeres by top scientists.

Francis Collins, MD,PHD is the Director of national Institutes of Health is leading the research on a treatment that might offer longer lives for children with Hutchinson Gilford progeria syndrome in children which is causing premature aging.

Children born with this disease die around the age of 12 usually because of heart disease.

Collins believes that the cause of this drastic aging is the result of damaged Telomeres or even total loss of them. Telomeres protect the DNA from damage as our cells replicate.

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Testing Telomere Health for Embryos

British Doctors have developed a new test for embryos that could drastically raise the success rate for couples who have IVF treatment. They are able to check embryos created at fertility clinics for biological signs of healthy growth and abnormal chromosomes.

In vitro fertilisation

In vitro fertilisation (IVF). The new test checks early-stage embryos for healthy mitochondria and normal telomeres. Photograph: Corbis

This will improve the success rate by being able to pick the best embryos for implanting from the regular 30% to 100%, so say the researchers at Oxford University.

The test is directed to check the mitochondria as well as the TELOMERES in the cells to make sure the genetic code inside the chromosomes is protected when The DNA is being replicated during cell division.
This test can be done on eggs as well as embryos and will cost £2,000.

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Common Misspellings for Telomeres

The Word Telomeres is becoming more and more famous not just in the world of science but to the public learning about them, in connection with aging or better said – anti-aging. Often misspelled as telemers or telemeres the correct spelling is Telomeres. Its name is derived from the Greek nouns telos (τέλος) “end” and merοs (μέρος, root: μερ-) “part.

In connection with Telemeres the same thing happens to the word Telomerase which often gets misspelled as telemerase.

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