Telomere Studies May Explain Rare Aging Disease in Children

Study of children with rare case of genetic mutation that causes drastic early aging and death is now being linked to short or missing Telomeres by top scientists.

Francis Collins, MD,PHD is the Director of national Institutes of Health is leading the research on a treatment that might offer longer lives for children with Hutchinson Gilford progeria syndrome in children which is causing premature aging.

Children born with this disease die around the age of 12 usually because of heart disease.

Collins believes that the cause of this drastic aging is the result of damaged Telomeres or even total loss of them. Telomeres protect the DNA from damage as our cells replicate.

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Testing Telomere Health for Embryos

British Doctors have developed a new test for embryos that could drastically raise the success rate for couples who have IVF treatment. They are able to check embryos created at fertility clinics for biological signs of healthy growth and abnormal chromosomes.

In vitro fertilisation

In vitro fertilisation (IVF). The new test checks early-stage embryos for healthy mitochondria and normal telomeres. Photograph: Corbis

This will improve the success rate by being able to pick the best embryos for implanting from the regular 30% to 100%, so say the researchers at Oxford University.

The test is directed to check the mitochondria as well as the TELOMERES in the cells to make sure the genetic code inside the chromosomes is protected when The DNA is being replicated during cell division.
This test can be done on eggs as well as embryos and will cost £2,000.

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Common Misspellings for Telomeres

The Word Telomeres is becoming more and more famous not just in the world of science but to the public learning about them, in connection with aging or better said – anti-aging. Often misspelled as telemers or telemeres the correct spelling is Telomeres. Its name is derived from the Greek nouns telos (τέλος) “end” and merοs (μέρος, root: μερ-) “part.

In connection with Telemeres the same thing happens to the word Telomerase which often gets misspelled as telemerase.

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Test- How Much Longer Will You Live

Scientist have developed a test in which they can tell you how much longer your biological clock will be ticking or in other words when you will die. In this test they measure the telomeres (the protective caps on the ends of chromosomes). The theory is based on the fact that our Telomeres shorten and with that determine our lifespan. Although times moves at a uniform rate, people age in differently.
It is questioned if this is a waste of time or a handy indicator of how well (or badly) the body is ageing.

Many aspects cause the body to age including lifestyle, nutrition, environment and genes. Essentially looking at the length of someone’s Telomeres they know whether one has become biologically younger or older than other’s born at around the same time.

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Reverse Aging

Premature aging can be reversed by reactivating an enzyme that protects the tips of chromosomes, as a study in mice suggests.

Mice were engineered to lack the enzyme telomerase and were shown to become prematurely decrepit. However, they bounced back to health when the enzyme was replaced. The finding, published online in “Nature”, hints that some disorders, characterized by early aging could be treated by boosting telomerase activity.

It also offers the possibility that normal human aging could be slowed by reawakening the enzyme in cells where it has stopped working, says Ronald DePinho, a cancer geneticist at the Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts, who led the new study. “This has implications for thinking about telomerase as a serious anti-aging intervention.

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